Abstract
Systematic simplification of the molecular structures of epicatechin gallate and epigallocatechin gallate to determine the minimum structural characteristics necessary for HIV-1 reverse transcriptase inhibition in vitro resulted in several compounds that strongly inhibited the native as well as the A17 double mutant (K103N Y181C) enzyme, which is normally insensitive to most known nonnucleoside inhibitors.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catechin / analogs & derivatives*
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Catechin / chemistry
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Catechin / pharmacology*
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HIV Reverse Transcriptase / antagonists & inhibitors*
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HIV Reverse Transcriptase / genetics
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Mutation
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / pharmacology*
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Structure-Activity Relationship
Substances
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Reverse Transcriptase Inhibitors
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catechin gallate
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Catechin
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epicatechin gallate
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epigallocatechin gallate
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HIV Reverse Transcriptase